3f9n Summary

pdbe.org/3f9n
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Crystal structure of chk1 kinase in complex with inhibitor 38

The structure was published by Converso, A., Hartingh, T., Garbaccio, R.M., et al., Jezequel-Sur, S.M., Zuck, P.D., and Hartman, G.D., in 2009 in a paper entitled "Development of thioquinazolinones, allosteric Chk1 kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Serine/threonine-protein kinase Chk1. This molecule has the UniProt identifier O14757 (CHK1_HUMAN)search. The sample contained 322 residues which is < 90% of the natural sequence. Out of 322 residues 253 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase Chk1 O14757 (2-307) (CHK1_HUMAN)search Homo sapienssearch < 90% 322 78%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14757 (2 - 307) Serine/threonine-protein kinase Chk1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (O14757) protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch