Crystal structure of chk1 kinase in complex with inhibitor 38
The structure was published by Converso, A., Hartingh, T., Garbaccio, R.M., et al., Jezequel-Sur, S.M., Zuck, P.D., and Hartman, G.D., in 2009 in a paper entitled "Development of thioquinazolinones, allosteric Chk1 kinase inhibitors." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2008.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Serine/threonine-protein kinase Chk1. This molecule has the UniProt identifier O14757 (CHK1_HUMAN). The sample contained 322 residues which is < 90% of the natural sequence. Out of 322 residues 253 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: