3f9m Summary


Human pancreatic glucokinase in complex with glucose and activator showing a mobile flap

The structure was published by Petit, P., Antoine, M., Ferry, G., et al., Gluais, L., Vincentelli, R., and Vuillard, L., in 2011 in a paper entitled "The active conformation of human glucokinase is not altered by allosteric activators" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 470 residues which is 98% of the natural sequence. Out of 470 residues 451 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase P35557 (12-465) (HXK4_HUMAN)search Homo sapienssearch 97% 470 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (12 - 465) Glucokinase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P35557) Hexokinase; domain 1search, Nucleotidyltransferase; domain 5search PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P35557) carbohydrate metabolic processsearch cellular response to insulin stimulussearch phosphorylationsearch hexose transportsearch carbohydrate phosphorylationsearch positive regulation of cytosolic calcium ion concentrationsearch detection of glucosesearch pathogenesissearch NADP metabolic processsearch negative regulation of gluconeogenesissearch glucose homeostasissearch response to glucosesearch regulation of potassium ion transportsearch glycolytic processsearch glucose metabolic processsearch positive regulation of phosphorylationsearch glucose transportsearch regulation of glucose transportsearch transmembrane transportsearch regulation of insulin secretionsearch cellular response to leptin stimulussearch glycogen biosynthetic processsearch cellular glucose homeostasissearch positive regulation of glycolytic processsearch calcium ion importsearch lipid homeostasissearch cellular response to glucose starvationsearch positive regulation of insulin secretionsearch metabolic processsearch glucose 6-phosphate metabolic processsearch positive regulation of glycogen biosynthetic processsearch negative regulation of epinephrine secretionsearch endocrine pancreas developmentsearch regulation of glycolytic processsearch second-messenger-mediated signalingsearch small molecule metabolic processsearch fructose 2,6-bisphosphate metabolic processsearch phosphotransferase activity, alcohol group as acceptorsearch ATP bindingsearch hexokinase activitysearch catalytic activitysearch glucose bindingsearch protein bindingsearch protein phosphatase bindingsearch fructokinase activitysearch glucokinase activitysearch transferase activitysearch ADP bindingsearch kinase activitysearch magnesium ion bindingsearch mannokinase activitysearch nucleotide bindingsearch actin filamentsearch secretory granulesearch nucleoplasmsearch cytosolsearch cytoplasmsearch mitochondrionsearch nucleussearch basal cortexsearch cell cortexsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch