3f7z Summary

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X-ray Co-Crystal Structure of Glycogen Synthase Kinase 3beta in Complex with an Inhibitor

The structure was published by Saitoh, M., Kunitomo, J., Kimura, E., et al., Textor, G.S., Snell, G.P., and Itoh, F., in 2009 in a paper entitled "Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (35-383) (GSK3B_HUMAN)search Homo sapienssearch 91% 350 97%
B Glycogen synthase kinase-3 beta P49841 (35-383) (GSK3B_HUMAN)search Homo sapienssearch 91% 350 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (35 - 383) Glycogen synthase kinase-3 beta Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P49841) transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein kinase activitysearch ATP bindingsearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch