3f7d Summary


SF-1 LBD bound by phosphatidylcholine

The structure was published by Sablin, E.P., Blind, R.D., Krylova, I.N., et al., Williams, J.D., Fletterick, R.J., and Ingraham, H.A., in 2009 in a paper entitled "Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely nuclear receptor SF-1 and Peroxisome proliferator-activated receptor gamma coactivator 1-alpha.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A nuclear receptor SF-1 P33242 (219-462) (STF1_MOUSE)search Mus musculussearch < 90% 244 97%
B Peroxisome proliferator-activated receptor gamma coactivator 1-alpha O70343 (137-150) (PRGC1_MOUSE)search Mus musculussearch < 90% 14 71%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P33242 (219 - 462) nuclear receptor SF-1 Mus musculus
O70343 (137 - 150) Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P33242) sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch DNA bindingsearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch