3f7b Summary


Crystal Structure of soluble domain of CA4 in complex with small molecule.

The structure was published by Vernier, W., Chong, W., Rewolinski, D., et al., Nukui, S., Ornelas, M., and Reyner, E., in 2010 in a paper entitled "Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.05 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Carbonic anhydrase 4.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 4 P22748 (19-284) (CAH4_HUMAN)search Homo sapienssearch 90% 266 96%
B Carbonic anhydrase 4 P22748 (19-284) (CAH4_HUMAN)search Homo sapienssearch 90% 266 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P22748 (19 - 284) Carbonic anhydrase 4 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P22748) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (P22748) basolateral plasma membranesearch rough endoplasmic reticulumsearch endoplasmic reticulum-Golgi intermediate compartmentsearch Golgi apparatussearch trans-Golgi networksearch plasma membranesearch cell surfacesearch membranesearch apical plasma membranesearch sarcoplasmic reticulumsearch transport vesicle membranesearch secretory granule membranesearch anchored component of membranesearch anchored component of external side of plasma membranesearch brush border membranesearch sarcolemmasearch anchored component of plasma membranesearch perinuclear region of cytoplasmsearch extracellular vesicular exosomesearch carbonate dehydratase activitysearch protein bindingsearch zinc ion bindingsearch lyase activitysearch metal ion bindingsearch one-carbon metabolic processsearch bicarbonate transportsearch response to drugsearch small molecule metabolic processsearch organ developmentsearch response to steroid hormonesearch

Chain InterPro annotation
A, B Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase, CA4search Carbonic anhydrase, alpha-classsearch