3f75 Summary


Activated Toxoplasma gondii cathepsin L (TgCPL) in complex with its propeptide

The structure was published by Larson, E.T., Parussini, F., Huynh, M.H., et al., Bogyo, M., Merritt, E.A., and Carruthers, V.B., in 2009 in a paper entitled "Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.99 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Cathepsin L Protease and Cathepsin L Propeptide.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cathepsin L Protease Q6DMN0 (199-422) (Q6DMN0_TOXGO)search Toxoplasma gondiisearch < 90% 224 99%
P Cathepsin L Propeptide Q6DMN0 (105-198) (Q6DMN0_TOXGO)search Toxoplasma gondiisearch < 90% 106 70%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q6DMN0 (199 - 422) Cathepsin L Protease Toxoplasma gondii RH

Chain Structural classification (CATH) Sequence family (Pfam)
A Cysteine proteinasessearch Papain family cysteine proteasesearch
P Cathepsin propeptide inhibitor domain (I29)search

Chain ID Molecular function (GO) Biological process (GO)
A (Q6DMN0) cysteine-type peptidase activitysearch proteolysissearch
P (Q6DMN0) cysteine-type peptidase activitysearch

Chain InterPro annotation
A Cysteine peptidase, cysteine active sitesearch Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Cysteine peptidase, histidine active sitesearch Cysteine peptidase, asparagine active sitesearch
P Peptidase C1Asearch Proteinase inhibitor I29, cathepsin propeptidesearch