3f69 Summary


Crystal structure of the Mycobacterium tuberculosis PknB mutant kinase domain in complex with KT5720

The structure was published by Mieczkowski, C., Iavarone, A.T., and Alber, T., in 2008 in a paper entitled "Auto-activation mechanism of the Mycobacterium tuberculosis PknB receptor Ser/Thr kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Serine/threonine-protein kinase pknB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase pknB P9WI81 (1-308) (PKNB_MYCTU)search Mycobacterium tuberculosis H37Rvsearch < 90% 311 90%
B Serine/threonine-protein kinase pknB P9WI81 (1-308) (PKNB_MYCTU)search Mycobacterium tuberculosis H37Rvsearch < 90% 311 90%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P9WI81 (1 - 308) Serine/threonine-protein kinase pknB Mycobacterium tuberculosis

Chain Structural classification (CATH)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search

Chain ID Molecular function (GO) Biological process (GO)
A, B (P9WI81) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch