3f69 Summary

pdbe.org/3f69
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Crystal structure of the Mycobacterium tuberculosis PknB mutant kinase domain in complex with KT5720

The structure was published by Mieczkowski, C., Iavarone, A.T., and Alber, T., in 2008 in a paper entitled "Auto-activation mechanism of the Mycobacterium tuberculosis PknB receptor Ser/Thr kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Serine/threonine-protein kinase pknB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase pknB P9WI81 (1-308) (PKNB_MYCTU)search Mycobacterium tuberculosis H37Rvsearch < 90% 311 90%
B Serine/threonine-protein kinase pknB P9WI81 (1-308) (PKNB_MYCTU)search Mycobacterium tuberculosis H37Rvsearch < 90% 311 90%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P9WI81 (1 - 308) Serine/threonine-protein kinase pknB Mycobacterium tuberculosis

Chain Structural classification (CATH)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search

Chain ID Molecular function (GO) Biological process (GO)
A, B (P9WI81) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch