3f5u Summary

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Crystal structure of the death associated protein kinase in complex with AMPPNP and Mg2+

The structure was published by McNamara, L.K., Watterson, D.M., and Brunzelle, J.S., in 2009 in a paper entitled "Structural insight into nucleotide recognition by human death-associated protein kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Death-associated protein kinase 1. This molecule has the UniProt identifier P53355 (DAPK1_HUMAN)search. The sample contained 295 residues which is < 90% of the natural sequence. Out of 295 residues 280 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Death-associated protein kinase 1 P53355 (1-285) (DAPK1_HUMAN)search Homo sapienssearch < 90% 295 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P53355 (1 - 285) Death-associated protein kinase 1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P53355) protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Myosin light chain kinase-relatedsearch Death-associated protein kinase 1search