3f5c Summary

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Structure of Dax-1:LRH-1 complex

The structure was published by Sablin, E.P., Woods, A., Krylova, I.N., Hwang, P., Ingraham, H.A., and Fletterick, R.J., in 2008 in a paper entitled "The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Nuclear receptor subfamily 5 group A member 2 and Nuclear receptor subfamily 0 group B member 1.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Nuclear receptor subfamily 5 group A member 2 P45448 (313-560) (NR5A2_MOUSE)search Mus musculussearch < 90% 248 97%
B Nuclear receptor subfamily 0 group B member 1 Q61066 (205-472) (NR0B1_MOUSE)search Mus musculussearch < 90% 268 68%
C Nuclear receptor subfamily 0 group B member 1 Q61066 (205-472) (NR0B1_MOUSE)search Mus musculussearch < 90% 268 68%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P45448 (313 - 560) Nuclear receptor subfamily 5 group A member 2 Mus musculus
Q61066 (205 - 472) Nuclear receptor subfamily 0 group B member 1 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
B, C Ligand-binding domain of nuclear hormone receptorsearch, Nuclear receptor repeatsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P45448) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch nucleussearch
B, C (Q61066) steroid hormone mediated signaling pathwaysearch regulation of transcription, DNA-templatedsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
B, C Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch Nuclear receptor repeatsearch