Crystal structure of human Pim-1 in complex with DAPPA
The structure was published by Qian, K., Wang, L., Cywin, C.L., et al., Welzel, M., Wolak, J., and Morwick, T., in 2009 in a paper entitled "Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2008.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Proto-oncogene serine/threonine-protein kinase Pim-1. This molecule has the UniProt identifier P11309 (PIM1_HUMAN). The sample contained 300 residues which is < 90% of the natural sequence. Out of 300 residues 277 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: