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Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT

Source organism: Human alphaherpesvirus 1 strain 17
Biochemical function: ATP binding
Biological process: TMP biosynthetic process
Cellular component: not assigned

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EC 2.7.1.21: Thymidine kinase

Reaction catalysed:
ATP + thymidine = ADP + thymidine 5'-phosphate
Systematic name:
ATP:thymidine 5'-phosphotransferase
Alternative Name(s):
  • 2'-deoxythymidine kinase
  • Deoxythymidine kinase (phosphorylating)
  • Thymidine kinase (phosphorylating)

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00693
Domain description: Thymidine kinase from herpesvirus
Occurring in:
  1. Thymidine kinase
The deposited structure of PDB entry 3f0t contains 2 copies of Pfam domain PF00693 (Thymidine kinase from herpesvirus) in Thymidine kinase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Thymidine kinase
IPR001889
Domain description: Herpesvirus thymidine kinase
Occurring in:
  1. Thymidine kinase

Structure domain

CATH CATH domain
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Thymidine kinase
The deposited structure of PDB entry 3f0t contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in Thymidine kinase. Showing 1 copy in chain B.

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