3ezv Summary


CDK-2 with indazole inhibitor 9 bound at its active site

The structure was published by Trujillo, J.I., Kiefer, J.R., Huang, W., et al., Christine, L., Compton, R., and Li, X., in 2009 in a paper entitled "2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-zeta inhibitor" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.99 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 300 residues which is 100% of the natural sequence. Out of 300 residues 276 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 300 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P24941) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P24941) transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein bindingsearch nucleotide bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch transferase activitysearch histone kinase activitysearch kinase activitysearch metal ion bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch cyclin bindingsearch nucleoplasmsearch endosomesearch nucleussearch cyclin-dependent protein kinase holoenzyme complexsearch cytoplasmsearch cytoskeletonsearch cytosolsearch condensed chromosomesearch Cajal bodysearch centrosomesearch microtubule organizing centersearch transcription factor complexsearch X chromosomesearch chromosome, telomeric regionsearch Y chromosomesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch cell divisionsearch cell cyclesearch centrosome duplicationsearch protein phosphorylationsearch cellular response to DNA damage stimulussearch potassium ion transportsearch Ras protein signal transductionsearch mitotic cell cyclesearch positive regulation of transcription, DNA-templatedsearch DNA replicationsearch positive regulation of cell proliferationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch phosphorylationsearch mitotic G1 DNA damage checkpointsearch histone phosphorylationsearch G2/M transition of mitotic cell cyclesearch positive regulation of DNA-dependent DNA replication initiationsearch blood coagulationsearch cellular response to nitric oxidesearch meiotic nuclear divisionsearch mitotic nuclear divisionsearch regulation of gene silencingsearch DNA repairsearch G1/S transition of mitotic cell cyclesearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch