3ezg Summary


Crystal structure of E18Q DJ-1 with oxidized C106

The structure was published by Blackinton, J., Lakshminarasimhan, M., Thomas, K.J., et al., Raza, A.S., Cookson, M.R., and Wilson, M.A., in 2009 in a paper entitled "Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.15 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Protein DJ-1. This molecule has the UniProt identifier Q99497 (PARK7_HUMAN)search. The sample contained 196 residues which is 100% of the natural sequence. Out of 196 residues 187 were observed and are deposited in the PDB.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein DJ-1 Q99497 (1-189) (PARK7_HUMAN)search Homo sapienssearch 99% 196 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q99497 (1 - 189) Protein DJ-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q99497) Rossmann foldsearch PF01965: DJ-1/PfpI familysearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (Q99497) synaptic transmission, dopaminergicsearch negative regulation of protein ubiquitinationsearch mitochondrion organizationsearch regulation of mitochondrial membrane potentialsearch negative regulation of death-inducing signaling complex assemblysearch negative regulation of ubiquitin-specific protease activitysearch autophagysearch regulation of neuron apoptotic processsearch cellular response to hydrogen peroxidesearch proteolysissearch positive regulation of tyrosine 3-monooxygenase activitysearch activation of protein kinase B activitysearch negative regulation of oxidative stress-induced cell deathsearch positive regulation of protein homodimerization activitysearch cellular response to oxidative stresssearch glycolate biosynthetic processsearch positive regulation of protein localization to nucleussearch negative regulation of hydrogen peroxide-induced neuron deathsearch positive regulation of gene expressionsearch methylglyoxal catabolic process to D-lactatesearch oxidation-reduction processsearch membrane hyperpolarizationsearch negative regulation of neuron deathsearch protein stabilizationsearch negative regulation of protein bindingsearch positive regulation of transcription from RNA polymerase II promotersearch negative regulation of protein phosphorylationsearch negative regulation of protein export from nucleussearch regulation of fibril organizationsearch negative regulation of apoptotic processsearch negative regulation of proteasomal ubiquitin-dependent protein catabolic processsearch negative regulation of extrinsic apoptotic signaling pathwaysearch positive regulation of superoxide dismutase activitysearch cellular response to reactive oxygen speciessearch negative regulation of hydrogen peroxide-induced cell deathsearch positive regulation of mitochondrial electron transport, NADH to ubiquinonesearch detoxification of copper ionsearch negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwaysearch membrane depolarizationsearch regulation of inflammatory responsesearch cellular response to glyoxalsearch positive regulation of dopamine biosynthetic processsearch Ras protein signal transductionsearch negative regulation of TRAIL-activated apoptotic signaling pathwaysearch positive regulation of oxidative phosphorylation uncoupler activitysearch hydrogen peroxide metabolic processsearch enzyme active site formation via L-cysteine sulfinic acidsearch protein deglycosylationsearch positive regulation of transcription regulatory region DNA bindingsearch negative regulation of protein catabolic processsearch dopamine uptake involved in synaptic transmissionsearch positive regulation of protein kinase B signalingsearch single fertilizationsearch regulation of TRAIL receptor biosynthetic processsearch positive regulation of sequence-specific DNA binding transcription factor activitysearch lactate biosynthetic processsearch positive regulation of androgen receptor activitysearch negative regulation of neuron apoptotic processsearch positive regulation of peptidyl-serine phosphorylationsearch glyoxal catabolic processsearch inflammatory responsesearch detoxification of mercury ionsearch negative regulation of oxidative stress-induced neuron deathsearch positive regulation of L-dopa decarboxylase activitysearch negative regulation of protein acetylationsearch negative regulation of protein K48-linked deubiquitinationsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaysearch response to hydrogen peroxidesearch negative regulation of protein kinase activitysearch negative regulation of cell deathsearch negative regulation of protein sumoylationsearch negative regulation of gene expressionsearch positive regulation of pyrroline-5-carboxylate reductase activitysearch regulation of androgen receptor signaling pathwaysearch negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwaysearch adult locomotory behaviorsearch positive regulation of L-dopa biosynthetic processsearch negative regulation of ubiquitin-protein transferase activitysearch negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathwaysearch positive regulation of interleukin-8 productionsearch mitochondrionsearch cytosolsearch nucleussearch plasma membranesearch mitochondrial intermembrane spacesearch mitochondrial matrixsearch cytoplasmsearch membrane raftsearch cell bodysearch extracellular vesicular exosomesearch chromatinsearch PML bodysearch axonsearch mitochondrial respiratory chain complex Isearch neuron projectionsearch membranesearch single-stranded DNA bindingsearch repressing transcription factor bindingsearch protein bindingsearch identical protein bindingsearch cytokine bindingsearch enzyme bindingsearch androgen receptor bindingsearch glyoxalase III activitysearch tyrosine 3-monooxygenase activator activitysearch peroxiredoxin activitysearch cuprous ion bindingsearch peptidase activitysearch cupric ion bindingsearch glyoxalase (glycolic acid-forming) activitysearch ubiquitin-specific protease bindingsearch transcription coactivator activitysearch protein homodimerization activitysearch receptor bindingsearch oxidoreductase activity, acting on peroxide as acceptorsearch ubiquitin-like protein conjugating enzyme bindingsearch double-stranded DNA bindingsearch small protein activating enzyme bindingsearch L-dopa decarboxylase activator activitysearch mercury ion bindingsearch core promoter bindingsearch RNA bindingsearch mRNA bindingsearch scaffold protein bindingsearch copper ion bindingsearch superoxide dismutase copper chaperone activitysearch transcription factor bindingsearch kinase bindingsearch hydrolase activitysearch

Chain InterPro annotation
A ThiJ/PfpIsearch DJ-1search Class I glutamine amidotransferase-likesearch