3eyb Summary

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Structural and functional insights into the ligand binding domain of a non-duplicated RXR from the invertebrate chordate amphioxus

The structure was published by Tocchini-Valentini, G.D., Rochel, N., Escriva, H., et al., Van Dorsselaer, A., Moras, D., and Laudet, V., in 2009 in a paper entitled "Structural and functional insights into the ligand-binding domain of a nonduplicated retinoid X nuclear receptor from the invertebrate chordate amphioxus" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.79 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Nuclear hormone receptor RXR.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Nuclear hormone receptor RXR Q8MX78 (266-484) (Q8MX78_BRAFL)search Branchiostoma floridaesearch < 90% 219 90%
B Nuclear hormone receptor RXR Q8MX78 (266-484) (Q8MX78_BRAFL)search Branchiostoma floridaesearch < 90% 219 90%
C Nuclear hormone receptor RXR Q8MX78 (266-484) (Q8MX78_BRAFL)search Branchiostoma floridaesearch < 90% 219 90%
D Nuclear hormone receptor RXR Q8MX78 (266-484) (Q8MX78_BRAFL)search Branchiostoma floridaesearch < 90% 219 90%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q8MX78 (266 - 484) Nuclear hormone receptor RXR Branchiostoma floridae

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B, C, D (Q8MX78) DNA bindingsearch steroid hormone receptor activitysearch zinc ion bindingsearch sequence-specific DNA binding transcription factor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B, C, D Retinoid X receptor/HNF4search Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch