3ey9 Summary

pdbe.org/3ey9
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Structural basis for membrane binding and catalytic activation of the peripheral membrane enzyme pyruvate oxidase from Escherichia coli

The structure was published by Neumann, P., Weidner, A., Pech, A., Stubbs, M.T., and Tittmann, K., in 2008 in a paper entitled "Structural basis for membrane binding and catalytic activation of the peripheral membrane enzyme pyruvate oxidase from Escherichia coli." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Pyruvate dehydrogenase [cytochrome].

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Pyruvate dehydrogenase [cytochrome] P07003 (1-572) (POXB_ECOLI)search Escherichia coli K-12search 96% 572 99%
B Pyruvate dehydrogenase [cytochrome] P07003 (1-572) (POXB_ECOLI)search Escherichia coli K-12search 96% 572 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P07003 (1 - 572) Pyruvate dehydrogenase [cytochrome] Escherichia coli

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P07003) Rossmann foldsearch PF00205: Thiamine pyrophosphate enzyme, central domainsearch, PF02775: Thiamine pyrophosphate enzyme, C-terminal TPP binding domainsearch, PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P07003) thiamine pyrophosphate bindingsearch magnesium ion bindingsearch catalytic activitysearch lipid bindingsearch oxidoreductase activitysearch pyruvate dehydrogenase (quinone) activitysearch oxidation-reduction processsearch membranesearch cytosolsearch plasma membranesearch

Chain InterPro annotation
A, B TPP-binding enzyme, conserved sitesearch Thiamine pyrophosphate enzyme, C-terminal TPP-bindingsearch Thiamine pyrophosphate enzyme, central domainsearch Thiamine pyrophosphate enzyme, N-terminal TPP-binding domainsearch DHS-like NAD/FAD-binding domainsearch Thiamin diphosphate-binding foldsearch