3erk Summary

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THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/SB220025

The structure was published by Wang, Z., Canagarajah, B.J., Boehm, J.C., et al., Abdel-Meguid, S., Adams, J.L., and Goldsmith, E.J., in 1998 in a paper entitled "Structural basis of inhibitor selectivity in MAP kinases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of EXTRACELLULAR REGULATED KINASE 2. This molecule has the UniProt identifier P63086 (MK01_RAT)search. The sample contained 364 residues which is 100% of the natural sequence. Out of 364 residues 350 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A EXTRACELLULAR REGULATED KINASE 2 P63086 (1-358) (MK01_RAT)search Rattus norvegicussearch 99% 364 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P63086 (1 - 358) EXTRACELLULAR REGULATED KINASE 2 Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P63086) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P63086) protein phosphorylationsearch regulation of stress-activated MAPK cascadesearch signal transductionsearch peptidyl-serine phosphorylationsearch response to exogenous dsRNAsearch B cell receptor signaling pathwaysearch cytosine metabolic processsearch positive regulation of cell migrationsearch intracellular signal transductionsearch regulation of protein stabilitysearch ERBB signaling pathwaysearch response to estrogensearch positive regulation of transcription, DNA-templatedsearch ERK1 and ERK2 cascadesearch response to epidermal growth factorsearch cellular response to organic substancesearch lipopolysaccharide-mediated signaling pathwaysearch response to lipopolysaccharidesearch apoptotic processsearch cell cyclesearch MAPK cascadesearch peptidyl-threonine phosphorylationsearch mammary gland epithelial cell proliferationsearch labyrinthine layer blood vessel developmentsearch positive regulation of cell proliferationsearch caveolin-mediated endocytosissearch positive regulation of peptidyl-threonine phosphorylationsearch regulation of early endosome to late endosome transportsearch sensory perception of painsearch phosphorylationsearch positive regulation of translationsearch negative regulation of cell differentiationsearch regulation of Golgi inheritancesearch MAPK import into nucleussearch regulation of cytoskeleton organizationsearch T cell receptor signaling pathwaysearch cellular response to DNA damage stimulussearch organ morphogenesissearch response to toxic substancesearch ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch nucleotide bindingsearch MAP kinase activitysearch protein kinase bindingsearch transcription factor bindingsearch protein bindingsearch mitogen-activated protein kinase kinase kinase bindingsearch kinase activitysearch phosphotyrosine bindingsearch phosphatase bindingsearch transferase activitysearch RNA polymerase II carboxy-terminal domain kinase activitysearch protein complexsearch late endosomesearch cytoplasmsearch cytosolsearch nucleussearch mitochondrionsearch microtubule cytoskeletonsearch early endosomesearch axonsearch cytoskeletonsearch perikaryonsearch nucleoplasmsearch dendrite cytoplasmsearch microtubule organizing centersearch Golgi apparatussearch spindlesearch caveolasearch mitotic spindlesearch focal adhesionsearch pseudopodiumsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, ERK1/2search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch