3erk Summary



The structure was published by Wang, Z., Canagarajah, B.J., Boehm, J.C., et al., Abdel-Meguid, S., Adams, J.L., and Goldsmith, E.J., in 1998 in a paper entitled "Structural basis of inhibitor selectivity in MAP kinases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of EXTRACELLULAR REGULATED KINASE 2. This molecule has the UniProt identifier P63086 (MK01_RAT)search. The sample contained 364 residues which is 100% of the natural sequence. Out of 364 residues 350 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A EXTRACELLULAR REGULATED KINASE 2 P63086 (1-358) (MK01_RAT)search Rattus norvegicussearch 99% 364 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P63086 (1 - 358) EXTRACELLULAR REGULATED KINASE 2 Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P63086) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P63086) focal adhesionsearch cytosolsearch nucleussearch mitochondrionsearch caveolasearch microtubule cytoskeletonsearch late endosomesearch microtubule organizing centersearch protein complexsearch extracellular vesicular exosomesearch cytoplasmsearch cytoskeletonsearch spindlesearch perikaryonsearch nucleoplasmsearch dendrite cytoplasmsearch axonsearch early endosomesearch Golgi apparatussearch mitotic spindlesearch pseudopodiumsearch response to toxic substancesearch response to epidermal growth factorsearch response to lipopolysaccharidesearch cell cyclesearch regulation of Golgi inheritancesearch negative regulation of cell differentiationsearch ERK1 and ERK2 cascadesearch regulation of cytoskeleton organizationsearch MAPK import into nucleussearch apoptotic processsearch protein phosphorylationsearch mammary gland epithelial cell proliferationsearch MAPK cascadesearch T cell receptor signaling pathwaysearch intracellular signal transductionsearch positive regulation of cell migrationsearch regulation of stress-activated MAPK cascadesearch cytosine metabolic processsearch signal transductionsearch peptidyl-serine phosphorylationsearch positive regulation of transcription, DNA-templatedsearch regulation of protein stabilitysearch response to estrogensearch peptidyl-threonine phosphorylationsearch ERBB signaling pathwaysearch cellular response to DNA damage stimulussearch cellular response to organic substancesearch cellular response to granulocyte macrophage colony-stimulating factor stimulussearch organ morphogenesissearch lipopolysaccharide-mediated signaling pathwaysearch positive regulation of peptidyl-threonine phosphorylationsearch positive regulation of translationsearch sensory perception of painsearch regulation of early endosome to late endosome transportsearch B cell receptor signaling pathwaysearch response to exogenous dsRNAsearch phosphorylationsearch caveolin-mediated endocytosissearch labyrinthine layer blood vessel developmentsearch positive regulation of cell proliferationsearch MAP kinase activitysearch protein bindingsearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch kinase activitysearch transferase activitysearch nucleotide bindingsearch RNA polymerase II carboxy-terminal domain kinase activitysearch transcription factor bindingsearch phosphotyrosine bindingsearch mitogen-activated protein kinase kinase kinase bindingsearch phosphatase bindingsearch protein kinase bindingsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, ERK1/2search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch