3eov Summary

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Crystal structure of cyclophilin from Leishmania donovani ligated with cyclosporin A

The structure was published by Venugopal, V., Datta, A.K., Bhattacharyya, D., Dasgupta, D., and Banerjee, R., in 2009 in a paper entitled "Structure of Cyclophilin from Leishmania Donovani Bound to Cyclosporin at 2.6 A Resolution: Correlation between Structure and Thermodynamic Data." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PEPTIDYL-PROLYL CIS-TRANS ISOMERASE and CYCLOSPORIN A.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PEPTIDYL-PROLYL CIS-TRANS ISOMERASE Q9U9R3 (22-187) (Q9U9R3_LEIDO)search Leishmania donovanisearch < 90% 172 96%
B PEPTIDYL-PROLYL CIS-TRANS ISOMERASE Q9U9R3 (22-187) (Q9U9R3_LEIDO)search Leishmania donovanisearch < 90% 172 96%
C CYCLOSPORIN A Not available
TOLYPOCLADIUM INFLATUMsearch Not available 11 100%
D CYCLOSPORIN A Not available
TOLYPOCLADIUM INFLATUMsearch Not available 11 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9U9R3 (22 - 187) PEPTIDYL-PROLYL CIS-TRANS ISOMERASE Leishmania donovani

Chain Sequence family (Pfam)
A, B Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLDsearch
C, D

Chain Molecule NORINE reference
C, DCYCLOSPORIN ANOR00033

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q9U9R3) peptidyl-prolyl cis-trans isomerase activitysearch protein foldingsearch protein peptidyl-prolyl isomerizationsearch

Chain InterPro annotation
A, B Cyclophilin-type peptidyl-prolyl cis-trans isomerase domainsearch Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved sitesearch Cyclophilin-type peptidyl-prolyl cis-trans isomerasesearch Cyclophilin-like domainsearch
C, D