spacer Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP494, a multitargeted kinase inhibitor
Accession P00523search
Keywords SH3 domain, Cell cycle, Nucleus, ATP-binding, Proto-oncogene, Mitochondrion, Lipoprotein, Complete proteome, Endosome, Alternative splicing, SH2 domain, Tyrosine-protein kinase, Cytoskeleton, Transferase, Cytoplasm, Immunity, Membrane, 3D-structure, S-nitrosylation, Reference proteome, Mitochondrion inner membrane, Cell membrane, Phosphoprotein, Nucleotide-binding, Kinase, Cell adhesion, Myristate
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Polymers A B
Enzyme nomenclature
EC number ExPASy BRENDA search
Polymers A, B
Name non-specific protein-tyrosine kinase
Comment Unlike EC, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families.