Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP121, a multitargeted kinase inhibitor
The structure was published by Apsel, B., Blair, J.A., Gonzalez, B., et al., Williams, R.L., Shokat, K.M., and Knight, Z.A., in 2008 in a paper entitled "Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.55 Å and deposited in 2008.
The experimental data on which the structure is based was also deposited.
This PDB entry contains multiple copies of the structure of Proto-oncogene tyrosine-protein kinase Src.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: