3ekn Summary

pdbe.org/3ekn
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Insulin receptor kinase complexed with an inhibitor

The structure was published by Chamberlain, S.D., Redman, A.M., Wilson, J.W., et al., Mook, R.A., Moorthy, G., and Patnaik, S., in 2009 in a paper entitled "Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Insulin receptor. This molecule has the UniProt identifier P06213 (INSR_HUMAN)search. The sample contained 307 residues which is < 90% of the natural sequence. Out of 307 residues 293 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Insulin receptor P06213 (1005-1310) (INSR_HUMAN)search Homo sapienssearch < 90% 307 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06213 (1005 - 1310) Insulin receptor Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P06213) protein kinase activitysearch transmembrane receptor protein tyrosine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class II, conserved sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch