› 3eiq

X-ray diffraction
3.5Å resolution

Crystal structure of Pdcd4-eIF4A

Released:
DOI: 10.2210/pdb3eiq/pdb
PDB entry 3eiq coloured by chain, front view.
PDB entry 3eiq coloured by chain, side view.
PDB entry 3eiq coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for translational inhibition by the tumour suppressor Pdcd4.
Loh PG, Yang HS, Walsh MA, Wang Q, Wang X, Cheng Z, Liu D, Song H
EMBO J 28 274-85 (2009)
PMID: 19153607

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158104 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Eukaryotic initiation factor 4A-I Chains: A, D
Molecule details ›
Chains: A, D
Length: 414 amino acids
Theoretical weight: 46.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P60842 (Residues: 1-406; Coverage: 100%)
Gene names: DDX2A, EIF4A, EIF4A1
Sequence domains:
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Programmed cell death protein 4 Chain: C
Molecule details ›
Chain: C
Length: 358 amino acids
Theoretical weight: 39.84 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q61823 (Residues: 120-469; Coverage: 75%)
Gene names: Ma3, Pdcd4, Tis
Sequence domains: MA3 domain
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P213
Unit cell:
a: 198.362Å b: 198.362Å c: 198.362Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.22 0.269
Expression system: Escherichia coli

Quick links

Citations

25 review citations

From unwinding to clamping - the DEAD box RNA helicase family.
Linder et al. (2011)
24 more

3 mentions without citation

Structural basis for translational inhibition by the tumour suppressor Pdcd4.
Loh et al. (2009)
2 more