CDK2/CyclinA complexed with a pyrazolopyridazine inhibitor
The structure was published by Stevens, K.L., Reno, M.J., Alberti, J.B., et al., Davis, S.T., Griffin, R.J., and Peel, M.R., in 2008 in a paper entitled "Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 3.15 Å and deposited in 2008.
The experimental data on which the structure is based was also deposited.
This PDB entry contains a complex of 2 biomacromolecules, namely Cell division protein kinase 2 and Cyclin-A2.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 2 unique UniProt proteins: