3ehq Summary

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Crystal Structure of Human Osteoclast Stimulating Factor

The structure was published by Tong, S., Zhou, H., Gao, Y., et al., Zhang, X., Teng, M., and Niu, L., in 2009 in a paper entitled "Crystal structure of human osteoclast stimulating factor" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.57 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Osteoclast-stimulating factor 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Osteoclast-stimulating factor 1 Q92882 (1-214) (OSTF1_HUMAN)search Homo sapienssearch 100% 222 81%
B Osteoclast-stimulating factor 1 Q92882 (1-214) (OSTF1_HUMAN)search Homo sapienssearch 100% 222 81%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q92882 (1 - 214) Osteoclast-stimulating factor 1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q92882) SH3 Domainssearch, Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeatsearch PF00018: SH3 domainsearch, PF12796: Ankyrin repeats (3 copies)search, PF13857: Ankyrin repeats (many copies)search

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (Q92882) SH3 domain bindingsearch protein bindingsearch intracellularsearch extracellular vesicular exosomesearch cytoplasmsearch ossificationsearch signal transductionsearch

Chain InterPro annotation
A, B SH3 domainsearch Ankyrin repeatsearch Ankyrin repeat-containing domainsearch