3eg1 Summary

pdbe.org/3eg1
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Crystal structure of the N114Q mutant of ABL-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions

The structure was published by Palencia, A., Camara-Artigas, A., Pisabarro, M.T., Martinez, J.C., and Luque, I., in 2010 in a paper entitled "Role of interfacial water molecules in proline-rich ligand recognition by the Src homology 3 domain of Abl." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Proto-oncogene tyrosine-protein kinase ABL1 and p41 peptide.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene tyrosine-protein kinase ABL1 P00519 (60-121) (ABL1_HUMAN)search Homo sapienssearch < 90% 63 92%
B Proto-oncogene tyrosine-protein kinase ABL1 P00519 (60-121) (ABL1_HUMAN)search Homo sapienssearch < 90% 63 92%
C p41 peptide Not available
Synthetic Not available 11 100%
D p41 peptide Not available
Synthetic Not available 11 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00519 (60 - 121) Proto-oncogene tyrosine-protein kinase ABL1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B SH3 Domainssearch SH3 domainsearch
C, D
Chain InterPro annotation
A, B SH3 domainsearch
C, D