3efw Summary

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Structure of AuroraA with pyridyl-pyrimidine urea inhibitor

The structure was published by Cee, V.J., Cheng, A.C., Romero, K., et al., Zhou, Y., Hughes, P., and Geuns-Meyer, S., in 2009 in a paper entitled "Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.29 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Serine/threonine-protein kinase 6.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase 6 O14965 (125-391) (AURKA_HUMAN)search Homo sapienssearch < 90% 267 90%
B Serine/threonine-protein kinase 6 O14965 (125-391) (AURKA_HUMAN)search Homo sapienssearch < 90% 267 90%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14965 (125 - 391) Serine/threonine-protein kinase 6 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (O14965) meiotic spindle organizationsearch protein phosphorylationsearch mitotic spindle organizationsearch centrosome organizationsearch cell cyclesearch meiotic cell cyclesearch mitotic centrosome separationsearch microtubule cytoskeleton organizationsearch regulation of signal transductionsearch mitotic cell cyclesearch ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch