3efl Summary

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Crystal structure of the VEGFR2 kinase domain in complex with motesanib

A publication describing this structure is not available. The depositing authors are Kim, J.L.search; Whittington, D.A.search; Long, A.M.search; Rose, P.search; Gu, Y.search; Zhao, H.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Vascular endothelial growth factor receptor 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Vascular endothelial growth factor receptor 2 P35968 (815-1171) (VGFR2_HUMAN)search Homo sapienssearch < 90% 314 91%
B Vascular endothelial growth factor receptor 2 P35968 (815-1171) (VGFR2_HUMAN)search Homo sapienssearch < 90% 314 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35968 (815 - 1171) Vascular endothelial growth factor receptor 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P35968) protein phosphorylationsearch vascular endothelial growth factor receptor signaling pathwaysearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch ATP bindingsearch protein tyrosine kinase activitysearch protein kinase activitysearch growth factor bindingsearch vascular endothelial growth factor-activated receptor activitysearch transferase activity, transferring phosphorus-containing groupssearch transmembrane receptor protein tyrosine kinase activitysearch membranesearch integral component of membranesearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class III, conserved sitesearch Tyrosine-protein kinase, active sitesearch Vascular endothelial growth factor receptor 2 (VEGFR2)search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch