3e92 Summary


Crystal Structure of P38 Kinase in Complex with A Biaryl Amide Inhibitor

The structure was published by Baldwin, I., Bamborough, P., Haslam, C.G., et al., Patel, S., Quinn, J., and Somers, D.O., in 2008 in a paper entitled "Kinase array design, back to front: Biaryl amides" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 371 residues which is 100% of the natural sequence. Out of 371 residues 349 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 371 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q16539) positive regulation of myoblast fusionsearch cellular response to lipopolysaccharidesearch toll-like receptor signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch response to muramyl dipeptidesearch regulation of transcription from RNA polymerase II promotersearch toll-like receptor TLR1:TLR2 signaling pathwaysearch peptidyl-serine phosphorylationsearch MyD88-dependent toll-like receptor signaling pathwaysearch skeletal muscle tissue developmentsearch toll-like receptor 4 signaling pathwaysearch innate immune responsesearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch chondrocyte differentiationsearch angiogenesissearch protein phosphorylationsearch cellular response to vascular endothelial growth factor stimulussearch positive regulation of blood vessel endothelial cell migrationsearch cell morphogenesissearch transcription, DNA-templatedsearch positive regulation of myoblast differentiationsearch neurotrophin TRK receptor signaling pathwaysearch osteoclast differentiationsearch MyD88-independent toll-like receptor signaling pathwaysearch cellular component movementsearch lipopolysaccharide-mediated signaling pathwaysearch response to lipopolysaccharidesearch toll-like receptor TLR6:TLR2 signaling pathwaysearch muscle cell differentiationsearch signal transductionsearch regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of erythrocyte differentiationsearch signal transduction in response to DNA damagesearch toll-like receptor 9 signaling pathwaysearch glucose metabolic processsearch positive regulation of transcription from RNA polymerase II promotersearch fatty acid oxidationsearch toll-like receptor 3 signaling pathwaysearch gene expressionsearch stress-induced premature senescencesearch intracellular signal transductionsearch positive regulation of myotube differentiationsearch cell surface receptor signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch response to stresssearch phosphorylationsearch myoblast differentiation involved in skeletal muscle regenerationsearch DNA damage checkpointsearch vascular endothelial growth factor receptor signaling pathwaysearch blood coagulationsearch activation of MAPK activitysearch toll-like receptor 5 signaling pathwaysearch regulation of transcription, DNA-templatedsearch chemotaxissearch RNA metabolic processsearch p38MAPK cascadesearch Ras protein signal transductionsearch toll-like receptor 10 signaling pathwaysearch positive regulation of protein import into nucleussearch cellular response to DNA damage stimulussearch platelet activationsearch apoptotic processsearch 3'-UTR-mediated mRNA stabilizationsearch stress-activated MAPK cascadesearch positive regulation of reactive oxygen species metabolic processsearch cellular response to ionizing radiationsearch positive regulation of muscle cell differentiationsearch mRNA metabolic processsearch striated muscle cell differentiationsearch cartilage condensationsearch toll-like receptor 2 signaling pathwaysearch protein bindingsearch protein kinase activitysearch kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch MAP kinase activitysearch nucleotide bindingsearch protein serine/threonine kinase activitysearch NFAT protein bindingsearch transferase activitysearch MAP kinase kinase activitysearch nucleoplasmsearch cytosolsearch mitochondrionsearch cytoplasmsearch nucleussearch extracellular vesicular exosomesearch spindle polesearch cellsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch