Crystal Structure of P38 Kinase in Complex with A Biaryl Amide Inhibitor
The structure was published by Baldwin, I., Bamborough, P., Haslam, C.G., et al., Patel, S., Quinn, J., and Somers, D.O., in 2008 in a paper entitled "Kinase array design, back to front: Biaryl amides" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2008.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN). The sample contained 371 residues which is 100% of the natural sequence. Out of 371 residues 349 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: