3e7c Summary


Glucocorticoid Receptor LBD bound to GSK866

The structure was published by Madauss, K.P., Bledsoe, R.K., Mclay, I., et al., Uings, I.J., Weingarten, G., and Williams, S.P., in 2008 in a paper entitled "The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.15 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Glucocorticoid receptor and Nuclear receptor coactivator 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucocorticoid receptor P04150 (521-777) (GCR_HUMAN)search Homo sapienssearch < 90% 257 96%
B Glucocorticoid receptor P04150 (521-777) (GCR_HUMAN)search Homo sapienssearch < 90% 257 96%
H Nuclear receptor coactivator 2 Q15596 (741-751) (NCOA2_HUMAN)search Homo sapienssearch < 90% 11 100%
D Nuclear receptor coactivator 2 Q15596 (741-751) (NCOA2_HUMAN)search Homo sapienssearch < 90% 11 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P04150 (521 - 777) Glucocorticoid receptor Homo sapiens
Q15596 (741 - 751) Nuclear receptor coactivator 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
H, D

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P04150) nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch steroid hormone receptor activitysearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
H, D