3e7c Summary

pdbe.org/3e7c
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Glucocorticoid Receptor LBD bound to GSK866

The structure was published by Madauss, K.P., Bledsoe, R.K., Mclay, I., et al., Uings, I.J., Weingarten, G., and Williams, S.P., in 2008 in a paper entitled "The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.15 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Glucocorticoid receptor and Nuclear receptor coactivator 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucocorticoid receptor P04150 (521-777) (GCR_HUMAN)search Homo sapienssearch < 90% 257 96%
B Glucocorticoid receptor P04150 (521-777) (GCR_HUMAN)search Homo sapienssearch < 90% 257 96%
H Nuclear receptor coactivator 2 Q15596 (741-751) (NCOA2_HUMAN)search Homo sapienssearch < 90% 11 100%
D Nuclear receptor coactivator 2 Q15596 (741-751) (NCOA2_HUMAN)search Homo sapienssearch < 90% 11 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P04150 (521 - 777) Glucocorticoid receptor Homo sapiens
Q15596 (741 - 751) Nuclear receptor coactivator 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
H, D

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P04150) nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch steroid hormone receptor activitysearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
H, D