3e6e Summary


Crystal structure of Alanine racemase from E.faecalis complex with cycloserine

The structure was published by Priyadarshi, A., Lee, E.H., Sung, M.W., et al., Lee, W.H., Kim, E.E., and Hwang, K.Y., in 2009 in a paper entitled "Structural insights into the alanine racemase from Enterococcus faecalis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Alanine racemase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Alanine racemase Q837J0 (1-371) (Q837J0_ENTFA)search Enterococcus faecalis V583search 100% 371 99%
B Alanine racemase Q837J0 (1-371) (Q837J0_ENTFA)search Enterococcus faecalis V583search 100% 371 99%
C Alanine racemase Q837J0 (1-371) (Q837J0_ENTFA)search Enterococcus faecalis V583search 100% 371 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q837J0 (1 - 371) Alanine racemase Enterococcus faecalis

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C (Q837J0) Lyase, Ornithine Decarboxylase; Chain A, domain 1search, Alanine racemasesearch PF00842: Alanine racemase, C-terminal domainsearch, PF01168: Alanine racemase, N-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B, C (Q837J0) alanine metabolic processsearch D-alanine biosynthetic processsearch isomerase activitysearch alanine racemase activitysearch pyridoxal phosphate bindingsearch catalytic activitysearch

Chain InterPro annotation
A, B, C Alanine racemasesearch Alanine racemase, N-terminalsearch Alanine racemase/group IV decarboxylase, C-terminalsearch Alanine racemase, C-terminalsearch Alanine racemase, pyridoxal-phosphate attachment sitesearch PLP-binding barrelsearch