3e64 Summary

pdbe.org/3e64
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Fragment based discovery of JAK-2 inhibitors

The structure was published by Antonysamy, S., Hirst, G., Park, F., et al., Steensma, R., Wilson, M., and Wong, M., in 2009 in a paper entitled "Fragment-based discovery of JAK-2 inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Tyrosine-protein kinase JAK2. This molecule has the UniProt identifier O60674 (JAK2_HUMAN)search. The sample contained 293 residues which is < 90% of the natural sequence. Out of 293 residues 289 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein kinase JAK2 O60674 (839-1131) (JAK2_HUMAN)search Homo sapienssearch < 90% 293 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O60674 (839 - 1131) Tyrosine-protein kinase JAK2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (O60674) ATP bindingsearch protein kinase activitysearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch