Fragment based discovery of JAK-2 inhibitors
The structure was published by Antonysamy, S., Hirst, G., Park, F., et al., Steensma, R., Wilson, M., and Wong, M., in 2009 in a paper entitled "Fragment-based discovery of JAK-2 inhibitors." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2008.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Tyrosine-protein kinase JAK2. This molecule has the UniProt identifier O60674 (JAK2_HUMAN). The sample contained 293 residues which is < 90% of the natural sequence. Out of 293 residues 289 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: