3e3b Summary

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Crystal structure of catalytic subunit of human protein kinase CK2alpha prime with a potent indazole-derivative inhibitor

The structure was published by Nakaniwa, T., Kinoshita, T., Sekiguchi, Y., et al., Ohno, H., Hirasawa, A., and Tsujimoto, G., in 2009 in a paper entitled "Structure of human protein kinase CK2alpha2 with a potent indazole-derivative inhibitor" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Casein kinase II subunit alpha'. This molecule has the UniProt identifier P19784 (CSK22_HUMAN)search. The sample contained 339 residues which is 95% of the natural sequence. Out of 339 residues 333 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
X Casein kinase II subunit alpha' P19784 (1-334) (CSK22_HUMAN)search Homo sapienssearch 95% 339 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P19784 (1 - 334) Casein kinase II subunit alpha' Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
X (P19784) Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
X (P19784) protein phosphorylationsearch Wnt signaling pathwaysearch transcription, DNA-templatedsearch mitotic cell cyclesearch regulation of transcription, DNA-templatedsearch cell cyclesearch phosphorylationsearch apoptotic processsearch axon guidancesearch mitotic spindle checkpointsearch regulation of cell cyclesearch protein bindingsearch nucleotide bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch transferase activitysearch protein N-terminus bindingsearch kinase activitysearch nucleussearch cytosolsearch PcG protein complexsearch

Chain InterPro annotation
X Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch