3dww Summary

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Electron crystallographic structure of human microsomal prostaglandin E synthase 1

The structure was published by Jegerschold, C., Pawelzik, S.C., Purhonen, P., et al., Morgenstern, R., Jakobsson, P.J., and Hebert, H., in 2008 in a paper entitled "Structural basis for induced formation of the inflammatory mediator prostaglandin E2" (abstract).

The structure was determined using Electron crystallography at a resolution of 3.5 Å and deposited in 2008.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Prostaglandin E synthase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin E synthase O14684 (1-152) (PTGES_HUMAN)search Homo sapienssearch 94% 158 89%
B Prostaglandin E synthase O14684 (1-152) (PTGES_HUMAN)search Homo sapienssearch 94% 158 89%
C Prostaglandin E synthase O14684 (1-152) (PTGES_HUMAN)search Homo sapienssearch 94% 158 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14684 (1 - 152) Prostaglandin E synthase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C (O14684) MAPEG domain-likesearch PF01124: MAPEG familysearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B, C (O14684) intracellular membrane-bounded organellesearch nuclear envelope lumensearch cytoplasmsearch perinuclear region of cytoplasmsearch membranesearch endoplasmic reticulum membranesearch integral component of membranesearch prostaglandin biosynthetic processsearch signal transductionsearch negative regulation of cell proliferationsearch response to calcium ionsearch prostaglandin metabolic processsearch response to cytokinesearch chronic inflammatory responsesearch arachidonic acid metabolic processsearch cyclooxygenase pathwaysearch response to retinoic acidsearch lipid metabolic processsearch acute inflammatory responsesearch fatty acid biosynthetic processsearch response to lipopolysaccharidesearch fatty acid metabolic processsearch small molecule metabolic processsearch response to organic cyclic compoundsearch isomerase activitysearch glutathione bindingsearch prostaglandin-E synthase activitysearch

Chain InterPro annotation
A, B, C Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) proteinsearch Membrane associated eicosanoid/glutathione metabolism-like domainsearch