3dvb Summary


X-ray crystal structure of mutant N62V human Carbonic Anhydrase II

The structure was published by Zheng, J., Avvaru, B.S., Tu, C., McKenna, R., and Silverman, D.N., in 2008 in a paper entitled "Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch protein bindingsearch lyase activitysearch bicarbonate transportsearch kidney developmentsearch odontogenesis of dentin-containing toothsearch small molecule metabolic processsearch response to zinc ionsearch response to pHsearch response to estrogensearch response to organic substancesearch regulation of intracellular pHsearch positive regulation of dipeptide transmembrane transportsearch morphogenesis of an epitheliumsearch angiotensin-activated signaling pathwaysearch secretionsearch response to steroid hormonesearch positive regulation of cellular pH reductionsearch positive regulation of bone resorptionsearch carbon dioxide transportsearch positive regulation of osteoclast differentiationsearch regulation of anion transportsearch one-carbon metabolic processsearch cytoplasmsearch microvillussearch cytosolsearch plasma membranesearch apical part of cellsearch axonsearch basolateral plasma membranesearch extracellular vesicular exosomesearch extracellular spacesearch membranesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch