3dv7 Summary

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Role of Hydrophilic Residues in Proton Transfer During Catalysis by Human Carbonic Anhydrase II (N62A)

The structure was published by Zheng, J., Avvaru, B.S., Tu, C., McKenna, R., and Silverman, D.N., in 2008 in a paper entitled "Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) basolateral plasma membranesearch cytoplasmsearch cytosolsearch extracellular spacesearch extracellular vesicular exosomesearch membranesearch microvillussearch plasma membranesearch apical part of cellsearch myelin sheathsearch axonsearch regulation of intracellular pHsearch positive regulation of bone resorptionsearch regulation of chloride transportsearch response to zinc ionsearch bicarbonate transportsearch regulation of anion transportsearch positive regulation of dipeptide transmembrane transportsearch odontogenesis of dentin-containing toothsearch one-carbon metabolic processsearch positive regulation of cellular pH reductionsearch response to pHsearch secretionsearch positive regulation of osteoclast differentiationsearch kidney developmentsearch positive regulation of synaptic transmission, GABAergicsearch morphogenesis of an epitheliumsearch response to estrogensearch response to steroid hormonesearch response to organic substancesearch small molecule metabolic processsearch angiotensin-activated signaling pathwaysearch zinc ion bindingsearch protein bindingsearch carbonate dehydratase activitysearch lyase activitysearch metal ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch