spacer
EBI PDBe PDBeView

PDBe Entry: 3du7 view

Tubulin-colchicine-phomopsin A: Stathmin-like domain complex
Summary
Header CELL CYCLEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 4.1 Å, R-factor: 21.781%, Free R-factor: 26.471%, Spacegroup: P 65
Released 21/10/2008, deposition: 17/07/2008, last revision: 09/12/2008
Authors Cormier, A.search; Marchand, M.search; Ravelli, R.B.search; Knossow, M.search; Gigant, B.search
Primary citation Structural insight into the inhibition of tubulin by vinca domain peptide ligands
EMBO REP.search vol:9, pag:1101-1106 (2008) [PubMed ID 18787557 ]search
Keywords alpha-tubulinsearch, beta-tubulinsearch, colchicinesearch, gtpasesearch, microtubulesearch, phomopsin Asearch, stathminsearch, tubulinsearch, GTP-bindingsearch, Nucleotide-bindingsearch, Phosphoproteinsearch, Alternative splicingsearch, Coiled coilsearch, CELL CYCLEsearch
Organism Bos taurus(cattle) 9913search(A C B D),Rattus norvegicus(Norway rat) 10116search(E)
UniProt Tubulin alpha-1C chain Q3ZCJ7search (A C)
Tubulin beta-2B chain Q6B856search (B D)
Stathmin-4 (Stathmin-like protein B3) (RB3) P63043search (E)
Related entries 1sa0, 1z2b
Polymers
Id Name Type UniProt Residues Observed
A, C Tubulin alpha-1C chain Protein Q3ZCJ7 (TBA1C_BOVIN)search
 449 97%
B, D Tubulin beta-2B chain Protein Q6B856 (TBB2B_BOVIN)search
 445 95%
E Stathmin-4 Protein P63043 (STMN4_RAT)search
 142 85%
Heterogens
Id Name Ligands
A, C MAGNESIUM ION MG search
D GUANOSINE-5'-TRIPHOSPHATE GTP search GDP search
B, D 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE CN2 search
B, D PHOMOPSIN A HOS search
spacer