› › Function and Biology

Catalytic core subunits (I and II) of cytochrome c oxidase from Rhodobacter sphaeroides complexed with deoxycholic acid

Source organism: Cereibacter sphaeroides
Biochemical function: metal ion binding
Biological process: proton transmembrane transport
Cellular component: respirasome

Quick links

EC 7.1.1.9: Cytochrome-c oxidase

Reaction catalysed:
4 ferrocytochrome c + O(2) + 8 H(+)(Side 1) = 4 ferricytochrome c + 4 H(2)O(Side 2)
Systematic name:
Ferrocytochrome-c:oxygen oxidoreductase
Alternative Name(s):
  • Complex IV (mitochondrial electron transport)
  • Cytochrome a3
  • Cytochrome aa3
  • Cytochrome ba(3)
  • Cytochrome bb3
  • Cytochrome caa(3)
  • Cytochrome cbb(3)
  • Cytochrome oxidase
  • Ferrocytochrome c oxidase
  • Indophenol oxidase
  • Indophenolase
  • NADH cytochrome c oxidase
  • Warburg's respiratory enzyme

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00116
Domain description: Cytochrome C oxidase subunit II, periplasmic domain
Occurring in:
  1. Cytochrome c oxidase subunit 2
The deposited structure of PDB entry 3dtu contains 2 copies of Pfam domain PF00116 (Cytochrome C oxidase subunit II, periplasmic domain) in Cytochrome c oxidase subunit 2. Showing 1 copy in chain B.

PF02790
Domain description: Cytochrome C oxidase subunit II, transmembrane domain
Occurring in:
  1. Cytochrome c oxidase subunit 2
The deposited structure of PDB entry 3dtu contains 2 copies of Pfam domain PF02790 (Cytochrome C oxidase subunit II, transmembrane domain) in Cytochrome c oxidase subunit 2. Showing 1 copy in chain B.

PF00115
Domain description: Cytochrome C and Quinol oxidase polypeptide I
Occurring in:
  1. Cytochrome c oxidase subunit 1
The deposited structure of PDB entry 3dtu contains 2 copies of Pfam domain PF00115 (Cytochrome C and Quinol oxidase polypeptide I) in Cytochrome c oxidase subunit 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000883
Domain description: Cytochrome c oxidase subunit I
Occurring in:
  1. Cytochrome c oxidase subunit 1
IPR002429
Domain description: Cytochrome c oxidase subunit II-like C-terminal
Occurring in:
  1. Cytochrome c oxidase subunit 2
IPR008972
Domain description: Cupredoxin
Occurring in:
  1. Cytochrome c oxidase subunit 2
IPR011759
Domain description: Cytochrome C oxidase subunit II, transmembrane domain
Occurring in:
  1. Cytochrome c oxidase subunit 2
IPR036257
Domain description: Cytochrome C oxidase subunit II, transmembrane domain superfamily
Occurring in:
  1. Cytochrome c oxidase subunit 2
IPR036927
Domain description: Cytochrome c oxidase-like, subunit I superfamily
Occurring in:
  1. Cytochrome c oxidase subunit 1
IPR001505
Domain description: Copper centre Cu(A)
Occurring in:
  1. Cytochrome c oxidase subunit 2
IPR014222
Domain description: Cytochrome c oxidase, subunit II
Occurring in:
  1. Cytochrome c oxidase subunit 2
IPR045187
Domain description: Cytochrome c/quinol oxidase subunit II
Occurring in:
  1. Cytochrome c oxidase subunit 2
IPR023615
Domain description: Cytochrome c oxidase, subunit I, copper-binding site
Occurring in:
  1. Cytochrome c oxidase subunit 1
IPR033944
Domain description: Cytochrome c oxidase subunit I domain
Occurring in:
  1. Cytochrome c oxidase subunit 1
IPR023616
Domain description: Cytochrome c oxidase-like, subunit I domain
Occurring in:
  1. Cytochrome c oxidase subunit 1
IPR014241
Domain description: Cytochrome c oxidase, subunit I bacterial type
Occurring in:
  1. Cytochrome c oxidase subunit 1

Structure domains

CATH CATH domains
2.60.40.420
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Cupredoxins - blue copper proteins
Occurring in:
  1. Cytochrome c oxidase subunit 2
The deposited structure of PDB entry 3dtu contains 2 copies of CATH domain 2.60.40.420 (Immunoglobulin-like) in Cytochrome c oxidase subunit 2. Showing 1 copy in chain B.
1.10.287.90
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helix Hairpins
Homology: Helix Hairpins
Occurring in:
  1. Cytochrome c oxidase subunit 2
The deposited structure of PDB entry 3dtu contains 2 copies of CATH domain 1.10.287.90 (Helix Hairpins) in Cytochrome c oxidase subunit 2. Showing 1 copy in chain B.
1.20.210.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Cytochrome C Oxidase; Chain A
Homology: Cytochrome c oxidase-like, subunit I domain
Occurring in:
  1. Cytochrome c oxidase subunit 1
The deposited structure of PDB entry 3dtu contains 2 copies of CATH domain 1.20.210.10 (Cytochrome C Oxidase; Chain A) in Cytochrome c oxidase subunit 1. Showing 1 copy in chain A.
SCOP SCOP annotations
49541
Class: All beta proteins
Fold: Cupredoxin-like
Superfamily: Cupredoxins
Occurring in:
  1. Cytochrome c oxidase subunit 2
The deposited structure of PDB entry 3dtu contains 2 copies of SCOP domain 49541 (Periplasmic domain of cytochrome c oxidase subunit II) in Cytochrome c oxidase subunit 2. Showing 1 copy in chain B.
81463
Class: Membrane and cell surface proteins and peptides
Fold: Transmembrane helix hairpin
Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region
Occurring in:
  1. Cytochrome c oxidase subunit 2
The deposited structure of PDB entry 3dtu contains 2 copies of SCOP domain 81463 (Cytochrome c oxidase subunit II-like, transmembrane region) in Cytochrome c oxidase subunit 2. Showing 1 copy in chain B.
81441
Class: Membrane and cell surface proteins and peptides
Fold: Cytochrome c oxidase subunit I-like
Superfamily: Cytochrome c oxidase subunit I-like
Occurring in:
  1. Cytochrome c oxidase subunit 1
The deposited structure of PDB entry 3dtu contains 2 copies of SCOP domain 81441 (Cytochrome c oxidase subunit I-like) in Cytochrome c oxidase subunit 1. Showing 1 copy in chain A.

Quick links