Crystal structure of mixed-lineage kinase MLK1 complexed with compound 16
The structure was published by Hudkins, R.L., Diebold, J.L., Tao, M., et al., Saporito, M.S., Scott, R.W., and Mallamo, J.P., in 2008 in a paper entitled "Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2008.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Mitogen-activated protein kinase kinase kinase 9. This molecule has the UniProt identifier P80192 (M3K9_HUMAN). The sample contained 271 residues which is < 90% of the natural sequence. Out of 271 residues 245 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: