3dtc Summary

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Crystal structure of mixed-lineage kinase MLK1 complexed with compound 16

The structure was published by Hudkins, R.L., Diebold, J.L., Tao, M., et al., Saporito, M.S., Scott, R.W., and Mallamo, J.P., in 2008 in a paper entitled "Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase kinase kinase 9. This molecule has the UniProt identifier P80192 (M3K9_HUMAN)search. The sample contained 271 residues which is < 90% of the natural sequence. Out of 271 residues 245 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase kinase kinase 9 P80192 (136-406) (M3K9_HUMAN)search Homo sapienssearch < 90% 271 90%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P80192 (136 - 406) Mitogen-activated protein kinase kinase kinase 9 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P80192) ATP bindingsearch protein tyrosine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch