3dt4 Summary


The structure of rat cytosolic PEPCK in complex with oxalate and GTP

The structure was published by Sullivan, S.M. and Holyoak, T., in 2008 in a paper entitled "Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.45 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Phosphoenolpyruvate carboxykinase, cytosolic [GTP].

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Phosphoenolpyruvate carboxykinase, cytosolic [GTP] P07379 (1-622) (PCKGC_RAT)search Rattus norvegicussearch 100% 624 99%
C Phosphoenolpyruvate carboxykinase, cytosolic [GTP] P07379 (1-622) (PCKGC_RAT)search Rattus norvegicussearch 100% 624 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P07379 (1 - 622) Phosphoenolpyruvate carboxykinase, cytosolic [GTP] Rattus norvegicus

Chain Structural classification (CATH) Sequence family (Pfam)
A, C (P07379) Phosphoenolpyruvate Carboxykinase, domain 1search, Phosphoenolpyruvate Carboxykinase, domain 2search, Phosphoenolpyruvate Carboxykinase; domain 3search PF00821: Phosphoenolpyruvate carboxykinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P07379) gluconeogenesissearch glucose homeostasissearch glycerol biosynthetic process from pyruvatesearch lipid metabolic processsearch oxaloacetate metabolic processsearch response to insulinsearch glucose metabolic processsearch internal protein amino acid acetylationsearch response to activitysearch purine nucleotide bindingsearch phosphoenolpyruvate carboxykinase activitysearch GTP bindingsearch phosphoenolpyruvate carboxykinase (GTP) activitysearch manganese ion bindingsearch GDP bindingsearch carboxylic acid bindingsearch magnesium ion bindingsearch metal ion bindingsearch nucleotide bindingsearch lyase activitysearch carboxy-lyase activitysearch cytosolsearch extracellular vesicular exosomesearch cytoplasmsearch

Chain InterPro annotation
A, C Phosphoenolpyruvate carboxykinase, GTP-utilisingsearch Phosphoenolpyruvate carboxykinase, N-terminalsearch Phosphoenolpyruvate carboxykinase, C-terminalsearch Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved sitesearch