3dt1 Summary


P38 Complexed with a quinazoline inhibitor

The structure was published by Herberich, B., Cao, G.Q., Chakrabarti, P.P., et al., Middleton, S., Wong, L.M., and Tasker, A.S., in 2008 in a paper entitled "Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 383 residues which is 100% of the natural sequence. Out of 383 residues 356 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 383 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) MAP kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein bindingsearch protein serine/threonine kinase activitysearch nucleotide bindingsearch kinase activitysearch NFAT protein bindingsearch MAP kinase kinase activitysearch transferase activitysearch protein phosphorylationsearch cell morphogenesissearch peptidyl-serine phosphorylationsearch intracellular signal transductionsearch osteoclast differentiationsearch skeletal muscle tissue developmentsearch regulation of transcription, DNA-templatedsearch positive regulation of reactive oxygen species metabolic processsearch positive regulation of erythrocyte differentiationsearch MAPK cascadesearch fatty acid oxidationsearch vascular endothelial growth factor receptor signaling pathwaysearch blood coagulationsearch RNA metabolic processsearch stress-activated MAPK cascadesearch MyD88-independent toll-like receptor signaling pathwaysearch gene expressionsearch TRIF-dependent toll-like receptor signaling pathwaysearch transcription, DNA-templatedsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch glucose metabolic processsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch p38MAPK cascadesearch response to muramyl dipeptidesearch regulation of transcription from RNA polymerase II promotersearch cartilage condensationsearch toll-like receptor 2 signaling pathwaysearch positive regulation of muscle cell differentiationsearch positive regulation of blood vessel endothelial cell migrationsearch toll-like receptor signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch muscle cell differentiationsearch stress-induced premature senescencesearch cellular response to lipopolysaccharidesearch MyD88-dependent toll-like receptor signaling pathwaysearch Ras protein signal transductionsearch positive regulation of myoblast differentiationsearch toll-like receptor 5 signaling pathwaysearch cellular response to ionizing radiationsearch apoptotic processsearch lipopolysaccharide-mediated signaling pathwaysearch innate immune responsesearch neurotrophin TRK receptor signaling pathwaysearch cellular response to DNA damage stimulussearch chemotaxissearch toll-like receptor TLR6:TLR2 signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch cellular component movementsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of myoblast fusionsearch toll-like receptor 10 signaling pathwaysearch DNA damage checkpointsearch chondrocyte differentiationsearch activation of MAPK activitysearch positive regulation of protein import into nucleussearch cell surface receptor signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch platelet activationsearch angiogenesissearch phosphorylationsearch signal transduction in response to DNA damagesearch signal transductionsearch cellular response to vascular endothelial growth factor stimulussearch response to lipopolysaccharidesearch toll-like receptor 3 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch 3'-UTR-mediated mRNA stabilizationsearch striated muscle cell differentiationsearch positive regulation of myotube differentiationsearch response to stresssearch mRNA metabolic processsearch cytosolsearch nucleussearch nucleoplasmsearch extracellular vesicular exosomesearch cytoplasmsearch spindle polesearch cellsearch mitochondrionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch