cFMS tyrosine kinase in complex with a pyridopyrimidinone inhibitor
The structure was published by Huang, H., Hutta, D.A., Rinker, J.M., et al., Yurkow, E., Manthey, C.L., and Player, M.R., in 2009 in a paper entitled "Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2008.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Macrophage colony-stimulating factor 1 receptor. This molecule has the UniProt identifier P07333 (CSF1R_HUMAN). The sample contained 335 residues which is < 90% of the natural sequence. Out of 335 residues 279 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):