3dpk Summary

pdbe.org/3dpk
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cFMS tyrosine kinase in complex with a pyridopyrimidinone inhibitor

The structure was published by Huang, H., Hutta, D.A., Rinker, J.M., et al., Yurkow, E., Manthey, C.L., and Player, M.R., in 2009 in a paper entitled "Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Macrophage colony-stimulating factor 1 receptor. This molecule has the UniProt identifier P07333 (CSF1R_HUMAN)search. The sample contained 335 residues which is < 90% of the natural sequence. Out of 335 residues 279 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Macrophage colony-stimulating factor 1 receptor P07333 (538-678) (CSF1R_HUMAN)search ,
P07333 (771-922) (CSF1R_HUMAN)search ,
P11362 (145-183) (FGFR1_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch ,
Homo sapienssearch
< 90% ,
< 90% ,
< 90%
335 83%


Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch, Immunoglobulin I-set domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P07333P11362) protein kinase activitysearch ATP bindingsearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch transmembrane receptor protein tyrosine kinase activitysearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class III, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch