3dnd Summary

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cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24

The structure was published by Orts, J., Tuma, J., Reese, M., et al., Wendt, K.U., Griesinger, C., and Carlomagno, T., in 2008 in a paper entitled "Crystallography-independent determination of ligand binding modes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.26 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely cAMP-dependent protein kinase catalytic subunit alpha and cAMP-dependent protein kinase inhibitor alpha.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A cAMP-dependent protein kinase catalytic subunit alpha P00517 (2-351) (KAPCA_BOVIN)search Bos taurussearch 96% 350 96%
I cAMP-dependent protein kinase inhibitor alpha P61926 (6-25) (IPKA_RABIT)search Oryctolagus cuniculussearch < 90% 20 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00517 (2 - 351) cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
P61926 (6 - 25) cAMP-dependent protein kinase inhibitor alpha

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00517) Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch
I cAMP-dependent protein kinase inhibitorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00517) ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase A regulatory subunit bindingsearch protein kinase bindingsearch cAMP-dependent protein kinase activitysearch nucleotide bindingsearch protein kinase activitysearch transferase activitysearch ubiquitin protein ligase bindingsearch protein bindingsearch kinase activitysearch protein phosphorylationsearch regulation of synaptic transmissionsearch mesoderm formationsearch positive regulation of protein export from nucleussearch peptidyl-serine phosphorylationsearch regulation of tight junction assemblysearch cellular response to parathyroid hormone stimulussearch cellular response to glucose stimulussearch positive regulation of cell cycle arrestsearch regulation of osteoblast differentiationsearch sperm capacitationsearch regulation of proteasomal protein catabolic processsearch phosphorylationsearch protein autophosphorylationsearch cytoplasmsearch membranesearch mitochondrionsearch neuromuscular junctionsearch nucleussearch plasma membranesearch centrosomesearch sperm midpiecesearch AMP-activated protein kinase complexsearch

Chain InterPro annotation
A Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
I cAMP-dependent protein kinase inhibitorsearch