3dko Summary


Complex between the kinase domain of human ephrin type-a receptor 7 (epha7) and inhibitor alw-ii-49-7

A publication describing this structure is not available. The depositing authors are Walker, J.R.search; Syeda, F.search; Gray, N.search; Butler-Cole, C.search; Bountra, C.search; Wolkstrom, M.search; Arrowsmith, C.H.search; Edwards, A.M.search; Bochkarev, A.search; Dhe-Paganon, S.search; Structural Genomics Consortium (SGC)search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Ephrin type-A receptor 7. This molecule has the UniProt identifier Q15375 (EPHA7_HUMAN)search. The sample contained 318 residues which is < 90% of the natural sequence. Out of 318 residues 270 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Ephrin type-A receptor 7 Q15375 (590-899) (EPHA7_HUMAN)search Homo sapienssearch < 90% 318 86%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q15375 (590 - 899) Ephrin type-A receptor 7 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch, Ephrin type-A receptor 2 transmembrane domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (Q15375) protein phosphorylationsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein tyrosine kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch Ephrin receptor, transmembrane domainsearch