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Aged Form of Human Butyrylcholinesterase Inhibited by Tabun

Source organism: Homo sapiens
Biochemical function: carboxylic ester hydrolase activity
Biological process: response to folic acid
Cellular component: blood microparticle

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EC 3.1.1.8: Cholinesterase

Reaction catalysed:
An acylcholine + H(2)O = choline + a carboxylate
Systematic name:
Acylcholine acylhydrolase
Alternative Name(s):
  • Benzoylcholinesterase
  • BtChoEase
  • Butyrylcholine esterase
  • Butyrylcholinesterase
  • Choline esterase
  • Choline esterase II (unspecific)
  • Non-specific cholinesterase
  • Propionylcholinesterase
  • Pseudocholineesterase
  • Pseudocholinesterase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00135
Domain description: Carboxylesterase family
Occurring in:
  1. Cholinesterase
The deposited structure of PDB entry 3dkk contains 1 copy of Pfam domain PF00135 (Carboxylesterase family) in Cholinesterase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000997
Domain description: Cholinesterase
Occurring in:
  1. Cholinesterase
IPR029058
Domain description: Alpha/Beta hydrolase fold
Occurring in:
  1. Cholinesterase
IPR019826
Domain description: Carboxylesterase type B, active site
Occurring in:
  1. Cholinesterase
IPR019819
Domain description: Carboxylesterase type B, conserved site
Occurring in:
  1. Cholinesterase
IPR002018
Domain description: Carboxylesterase, type B
Occurring in:
  1. Cholinesterase

Structure domain

CATH CATH domain
3.40.50.1820
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: alpha/beta hydrolase
Occurring in:
  1. Cholinesterase
The deposited structure of PDB entry 3dkk contains 1 copy of CATH domain 3.40.50.1820 (Rossmann fold) in Cholinesterase. Showing 1 copy in chain A.

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