3dk3 Summary

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Crystal structure of mutant ABL kinase domain in complex with small molecule fragment

A publication describing this structure is not available. The depositing authors are Lewis, H.A.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.02 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Proto-oncogene tyrosine-protein kinase ABL1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene tyrosine-protein kinase ABL1 Not available
Mus musculussearch Not available 293 91%
B Proto-oncogene tyrosine-protein kinase ABL1 Not available
Mus musculussearch Not available 293 91%


Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B () ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch