3dj5 Summary


Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 290.

A publication describing this structure is not available. The depositing authors are Elling, R.A.search; Erlanson, D.Asearch; Yang, W.search; Tangonan, B.T.search; Hansen, S.K.search; Romanowski, M.J.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of serine/threonine kinase 6. This molecule has the UniProt identifier P97477 (AURKA_MOUSE)search. The sample contained 272 residues which is < 90% of the natural sequence. Out of 272 residues 252 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A serine/threonine kinase 6 P97477 (116-381) (AURKA_MOUSE)search Mus musculussearch < 90% 272 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P97477 (116 - 381) serine/threonine kinase 6 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P97477) transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch