3dd8 Summary


Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD-486019 with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies

The structure was published by Temperini, C., Innocenti, A., Scozzafava, A., and Supuran, C.T., in 2008 in a paper entitled "Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) myelin sheathsearch extracellular vesicular exosomesearch microvillussearch cytosolsearch membranesearch plasma membranesearch basolateral plasma membranesearch cytoplasmsearch apical part of cellsearch axonsearch extracellular spacesearch bicarbonate transportsearch positive regulation of dipeptide transmembrane transportsearch one-carbon metabolic processsearch positive regulation of osteoclast differentiationsearch kidney developmentsearch small molecule metabolic processsearch regulation of intracellular pHsearch morphogenesis of an epitheliumsearch response to organic substancesearch positive regulation of bone resorptionsearch regulation of chloride transportsearch angiotensin-activated signaling pathwaysearch regulation of anion transportsearch positive regulation of cellular pH reductionsearch response to pHsearch positive regulation of synaptic transmission, GABAergicsearch response to steroid hormonesearch response to estrogensearch odontogenesis of dentin-containing toothsearch secretionsearch response to zinc ionsearch lyase activitysearch zinc ion bindingsearch carbonate dehydratase activitysearch metal ion bindingsearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch