3dd8 Summary

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Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD-486019 with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies

The structure was published by Temperini, C., Innocenti, A., Scozzafava, A., and Supuran, C.T., in 2008 in a paper entitled "Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch lyase activitysearch protein bindingsearch one-carbon metabolic processsearch small molecule metabolic processsearch positive regulation of osteoclast differentiationsearch positive regulation of cellular pH reductionsearch bicarbonate transportsearch response to pHsearch morphogenesis of an epitheliumsearch secretionsearch carbon dioxide transportsearch positive regulation of dipeptide transmembrane transportsearch regulation of intracellular pHsearch kidney developmentsearch odontogenesis of dentin-containing toothsearch regulation of anion transportsearch angiotensin-activated signaling pathwaysearch positive regulation of bone resorptionsearch response to steroid hormonesearch response to estrogensearch response to zinc ionsearch response to organic substancesearch cytoplasmsearch axonsearch apical part of cellsearch cytosolsearch basolateral plasma membranesearch membranesearch plasma membranesearch extracellular vesicular exosomesearch microvillussearch extracellular spacesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch