3dcc Summary

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Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties

The structure was published by Genis, C., Sippel, K.H., Case, N., et al., Silverman, D.N., Rosser, C.J., and McKenna, R., in 2009 in a paper entitled "Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) zinc ion bindingsearch carbonate dehydratase activitysearch protein bindingsearch lyase activitysearch metal ion bindingsearch cytosolsearch basolateral plasma membranesearch plasma membranesearch extracellular spacesearch apical part of cellsearch membranesearch axonsearch cytoplasmsearch extracellular vesicular exosomesearch myelin sheathsearch microvillussearch regulation of intracellular pHsearch response to steroid hormonesearch kidney developmentsearch positive regulation of osteoclast differentiationsearch regulation of chloride transportsearch bicarbonate transportsearch response to estrogensearch positive regulation of bone resorptionsearch one-carbon metabolic processsearch response to zinc ionsearch morphogenesis of an epitheliumsearch positive regulation of dipeptide transmembrane transportsearch regulation of anion transportsearch response to organic substancesearch positive regulation of cellular pH reductionsearch angiotensin-activated signaling pathwaysearch secretionsearch response to pHsearch positive regulation of synaptic transmission, GABAergicsearch odontogenesis of dentin-containing toothsearch small molecule metabolic processsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch