3dc9 Summary

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Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties

The structure was published by Genis, C., Sippel, K.H., Case, N., et al., Silverman, D.N., Rosser, C.J., and McKenna, R., in 2009 in a paper entitled "Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 96% 260 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) zinc ion bindingsearch carbonate dehydratase activitysearch arylesterase activitysearch protein bindingsearch lyase activitysearch metal ion bindingsearch regulation of intracellular pHsearch positive regulation of cellular pH reductionsearch kidney developmentsearch response to organic substancesearch bicarbonate transportsearch positive regulation of osteoclast differentiationsearch odontogenesis of dentin-containing toothsearch regulation of chloride transportsearch regulation of anion transportsearch small molecule metabolic processsearch positive regulation of bone resorptionsearch positive regulation of dipeptide transmembrane transportsearch angiotensin-activated signaling pathwaysearch morphogenesis of an epitheliumsearch response to zinc ionsearch secretionsearch positive regulation of synaptic transmission, GABAergicsearch one-carbon metabolic processsearch response to pHsearch response to estrogensearch cellular response to fluid shear stresssearch response to steroid hormonesearch extracellular exosomesearch axonsearch cytosolsearch membranesearch cytoplasmsearch plasma membranesearch extracellular spacesearch microvillussearch myelin sheathsearch apical part of cellsearch basolateral plasma membranesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch