3d8w Summary

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Use of a carbonic Anhydrase II, IX Active-site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties

The structure was published by Genis, C., Sippel, K.H., Case, N., et al., Silverman, D.N., Rosser, C.J., and McKenna, R., in 2009 in a paper entitled "Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase II P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase II Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) one-carbon metabolic processsearch positive regulation of dipeptide transmembrane transportsearch carbon dioxide transportsearch regulation of intracellular pHsearch regulation of anion transportsearch response to estrogensearch angiotensin-activated signaling pathwaysearch positive regulation of cellular pH reductionsearch response to pHsearch positive regulation of osteoclast differentiationsearch secretionsearch response to zinc ionsearch positive regulation of bone resorptionsearch bicarbonate transportsearch response to steroid hormonesearch morphogenesis of an epitheliumsearch small molecule metabolic processsearch odontogenesis of dentin-containing toothsearch response to organic substancesearch kidney developmentsearch cytoplasmsearch cytosolsearch apical part of cellsearch basolateral plasma membranesearch plasma membranesearch extracellular vesicular exosomesearch membranesearch extracellular spacesearch microvillussearch axonsearch carbonate dehydratase activitysearch metal ion bindingsearch protein bindingsearch zinc ion bindingsearch lyase activitysearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch