3d83 Summary


Crystal structure of P38 kinase in complex with a biphenyl amide inhibitor

The structure was published by Angell, R.M., Angell, T.D., Bamborough, P., et al., Smee, P.A., Somers, D.O., and Walker, A.L., in 2008 in a paper entitled "Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 349 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch protein bindingsearch protein kinase activitysearch MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch MAP kinase kinase activitysearch NFAT protein bindingsearch transferase activitysearch nucleotide bindingsearch kinase activitysearch protein phosphorylationsearch fatty acid oxidationsearch toll-like receptor signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch cellular response to ionizing radiationsearch glucose metabolic processsearch positive regulation of reactive oxygen species metabolic processsearch positive regulation of myoblast differentiationsearch striated muscle cell differentiationsearch positive regulation of blood vessel endothelial cell migrationsearch RNA metabolic processsearch neurotrophin TRK receptor signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch regulation of sequence-specific DNA binding transcription factor activitysearch osteoclast differentiationsearch cellular component movementsearch cell morphogenesissearch negative regulation of canonical Wnt signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch peptidyl-serine phosphorylationsearch transcription, DNA-templatedsearch toll-like receptor 3 signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch positive regulation of protein import into nucleussearch angiogenesissearch response to muramyl dipeptidesearch stress-induced premature senescencesearch response to stresssearch response to lipopolysaccharidesearch lipopolysaccharide-mediated signaling pathwaysearch cellular response to DNA damage stimulussearch chemotaxissearch cellular response to lipopolysaccharidesearch positive regulation of muscle cell differentiationsearch chondrocyte differentiationsearch intracellular signal transductionsearch positive regulation of myotube differentiationsearch cartilage condensationsearch p38MAPK cascadesearch skeletal muscle tissue developmentsearch mRNA metabolic processsearch cell surface receptor signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch regulation of transcription, DNA-templatedsearch gene expressionsearch signal transduction in response to DNA damagesearch activation of MAPK activitysearch platelet activationsearch toll-like receptor 5 signaling pathwaysearch signal transductionsearch apoptotic processsearch TRIF-dependent toll-like receptor signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch toll-like receptor TLR1:TLR2 signaling pathwaysearch positive regulation of myoblast fusionsearch positive regulation of erythrocyte differentiationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch phosphorylationsearch toll-like receptor 4 signaling pathwaysearch myoblast differentiation involved in skeletal muscle regenerationsearch Ras protein signal transductionsearch stress-activated MAPK cascadesearch blood coagulationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch DNA damage checkpointsearch toll-like receptor 2 signaling pathwaysearch muscle cell differentiationsearch innate immune responsesearch cytosolsearch nucleussearch nucleoplasmsearch cytoplasmsearch mitochondrionsearch cellsearch spindle polesearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch